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Leica CM3600 XP – Cryostat

A large-surface cryosectioning system

The Leica CM3600 XP primarily used to quantitively investigate the effect of labeled compounds, pharmaceuticals, and biologicals in pre-clinical studies. It can also be used for anatomical and morphological analysis of large objects, including cryoplaning for 3D reconstruction.

The CM3600 XP is the ideal solution for facilities requiring sectioning of large objects with documentation of all experiments, such as required for GLP.

Documentation of experimental parameters supports reproducibility of experiments for all research institutions.

  • Data Tracking for GLP Compliance

Windows PC operated instrument controller allows to manage access rights and provides an audit trail through a chronological list of events and alarms. Experimental data are recorded in protocols that can be tailored to the laboratory’s need.

  • Sectioning Large Objects

The heavy-duty microtome does not require fixation inside the stainless steel cryochamber and can be positioned to the user’s preference. The knife holder supports sectioning of specimens up to 450 x 150 x 200 mm (L,W,H) for very large objects.

  • Section Dehydration for QWBA

Quantitative whole-body autoradiography requires dehydration of frozen sections. The CM3600 XP features a twin compressor design to provide extra capacity for a constant cold air stream when used for dehydration.

  • Comfort and Safety

A knee-lever supports hands-free sectioning so that both hands are free for capturing the section on tape. Safety measurements, such as a lid retainer that locks the open lid, or the use of 24V illumination inside the cryochamber reduce the risk of injuries.

Sectioning thickness setting
1 – 500 μm, in 1 μm increments
Sectioning range 0 – 450 mm
Max. sectioning speed 80 mm/s
Knife retraction after sectioning stroke 50 – 250 μm
Total vertical stroke of knife 100 mm
Total specimen feed 450 mm
Specimen orientation via ball-and-socket joint Approx. 5° (x/y/z-axis)
Specimen orientation via large specimen stage (450 x 150 mm) Rotation around longitudinal axis (x-axis)
Maximum specimen size 450 x 150 x 200 mm
The Leica CM3600 XP is equipped with a commercially available computer with monitor, keyboard and mouse. For further information, please refer to the manual of the PC
Operating system  Windows®
Inner (cryochamber L x Hx W
1650 x 720 x 600 mm
Outer (L x H x W) 2800 x 1090 x 920 mm
Weight (total weight incl. microtome) 660 kg
Weight (microtome only) 190 kg