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Tundra Cryo – Transmission Electron Microscopy (TEM)

The Thermo Scientific Tundra Cryo-Transmission Electron Microscope (Cryo-TEM) allows you to perform structural analyses on challenging proteins and macromolecules with unprecedented ease of use, at a price point within the reach of many grants and funding sources.

Bringing cryo-electron microscopy to you

Whether you’re an experienced microscopist, or just starting out, the Thermo Scientific Tundra Cryo-Transmission Electron Microscope (Cryo-TEM) is a dedicated structural analysis solution designed to bring cryo-electron microscopy (cryo-EM) to your laboratory at an affordable price point. Simplified data collection and rapid sample loading/unloading make the Tundra Cryo-TEM a powerful tool for answering your most challenging research questions. With the Tundra Cryo-TEM, you can obtain structures at biologically relevant resolutions in-house or reliably prepare high-quality samples for further analysis on Thermo Scientific Krios or Glacios Cryo-TEMs.

  • X-FEG (extreme high-brightness field emission gun)
Accelerating voltage
  • Fixed accelerating voltage of 100 kV
Semi-automated sample loading
  • Cryo-preparation station for contamination free sample exchange
  • Sample transfer device for transfer of single AutoGrids to the microscope, with fixed cryo-box
  • High-resolution objective lens optimized for single particle analysis
  • Computerized specimen cryo-stage
Imaging options
  • High-performance Falcon C Direct Electron Detector for improved resolution capabilities
  • Standard Ceta-F CMOS Camera with dose fractionation, optimized for low-dose imaging
Room size requirements (L x W X H)
  • All in one room dimensions: 4.20 x 4.00 x 2.74 m (13.8 x 13.1 x 8.99 ft)
  • Dimensions with cryo-loading station in neighboring room: 4.00 x 3.80 x 2.74 m (13.1 x 12.5 x 8.99 ft)
  • AI-enabled and automated software solution that provides feedback during data collection and has an open application programming interface

The Tundra Cryo-TEM is equipped with a 100 kV high-brightness field emission gun (X-FEG) that allows for high resolution structure determination at routinely 3-5 Å. The Tundra Cryo-TEM can be installed with either the Falcon C Direct Electron Detector or Thermo Scientific Ceta F CMOS Detector. The Falcon C Direct Electron Detector provides a boost in contrast for single particle cryo-EM, improving resolution and obtaining results faster with less data to maximize your resolution efforts. Tundra Cryo-TEM with the Falcon C Direct Electron Detector makes it possible to efficiently solve protein structures 100 kDa or less.

  • Single Particle Cryo-EM
  • Drug Discovery Cryo TEM
  • Cryo TEM Sample Optimization
  • Room Temperature TEM