Automate the entire cell culture process to improve workflows and make assays more reliable and reproducible.
The CellXpress.ai™ Automated Cell Culture System is an AI-driven cell culture innovation hub that gives your team total control over demanding cell culture feeding and passaging schedules—eliminating time in the lab while maintaining a 24/7 schedule for growing and scaling multiple stem cell lines, spheroids, or organoids.
This revolutionary solution can give your lab the confidence in experimental outcomes to make key decisions sooner, achieve milestones faster, and get to clinic earlier—with lower attrition rates. All of it backed with the assurance of a full event log to confirm on-time feedings and critical task execution with complete digital microscopy records.
Automate your cell culture processes
Total control over demanding feeding and passaging schedules reduces hands-on time in the lab.
Improve your screening workflows
Around-the-clock operation maximizes productivity for growing and scaling multiple stem cell lines, spheroids, or organoids.
Develop reliable, reproducible assays
A machine learning-assisted solution standardizes the development process to deliver consistent, unbiased, and biologically relevant results at scale.
Complex biology simplified
An approachable, truly hands-off automated solution built by scientists, for scientists.
Built for continuous operation, you never have to worry about missing a feeding or passaging step. CellXpress.ai cell culture system provides workflow repeatability through automation and applies imaging-guided AI decision-making to ensure cell culture feeding and passaging events happen at the right time and event alerts keep you informed of your cell culture status.
Reliable, reproducible results
The CellXpress.ai cell culture system was designed with the biologist’s point of view in mind. With the intuitive protocol wizard, users avoid complex scripting. Instead, you are able to build your workflows with an easy-to-use interface that follows the logical flow of the cell culture process.
In addition, the CellXpress.ai cell culture system is intended to support a variety of model system workflows in both 2D and 3D and in both matrix and matrix-free environments.
3D organoid assays
The CellXpress.ai™ Automated Cell Culture System is a transformative solution for developing automated organoid assay protocols. This innovative system addresses the challenges of standardization, reproducibility, and scalability in 3D organoid culture and analysis. By integrating advanced hardware and software, including machine learning-based image analysis, the system automates critical processes such as media exchange, passaging, and endpoint assays. The research and methods presented here highlights the successful automation of workflows for iPSC, tumoroid, and adult stem cell-derived organoids, significantly enhancing throughput, consistency, and reliability. These advancements demonstrate the potential of automation to revolutionize organoid research, making it more efficient and scalable for drug discovery and personalized medicine applications.
3D spheroid assays
The development of efficient drug combinations for cancer therapy necessitates robust methods for testing drug efficacy. 3D cancer models, such as spheroids and tumoroids, are invaluable for cancer research and drug development due to their ability to closely mimic tumor structure and behavior. However, the complexity and manual nature of 3D assays have hindered their widespread adoption in high-throughput drug screening. The CellXpress.ai Automated Cell Culture System addresses these challenges by fully automating 3D spheroid assays, including plating, passaging, media exchanges, organoid monitoring, compound treatment, and endpoint assays. This automation significantly enhances the scalability, consistency, and efficiency of complex 3D cell-based assays, streamlining the discovery of new therapeutic targets and drug combinations.
Automated cell culture
The CellXpress.ai Automated Cell Culture System’s innovative use of decision making-based image analysis revolutionizes cell culture maintenance and expansion. The system integrates liquid handling, incubation, imaging, and AI-powered software to execute complex cell culture protocols with minimal human intervention. The decision-making capability, powered by real-time image analysis, enables the system to monitor cell growth and automatically trigger actions such as media exchanges and cell passaging. This groundbreaking approach not only boosts workflow efficiency and consistency but also drastically reduces the manual workload and error potential for researchers.
Intestinal organoids
Intestinal organoids are vital for advancing drug discovery and disease modeling due to their ability to mimic the physiological structure and function of human intestines. Our solutions, exemplified by the CellXpress.ai Automated Cell Culture System, address the challenges of assay complexity, reproducibility, and scalability that have hindered the widespread adoption of organoid-based screening methods. The CellXpress.ai system automates the entire 3D intestinal organoid culture workflow, including media exchange, plating, passaging, organoid monitoring, and endpoint assays. This automation significantly increases the number of organoid cultures that can be processed at once, ensures uniformity in the processes, and improves the precision of the results. These enhancements enable efficient high-throughput drug discovery and reliable toxicity testing. By leveraging machine learning and AI-powered image analysis, our system ensures reliable and reproducible results, helping researchers overcome traditional bottlenecks to significantly improve productivity in drug development and precision-medicine applications.
iPSC-derived culture
Induced pluripotent stem cells (iPSCs) are crucial for generating various cell types, organoids, and tissues, and for creating disease-specific phenotypes using CRISPR gene editing. However, the manual processes involved in iPSC cultures are labor-intensive and demanding. The CellXpress.ai Automated Cell Culture System automates the entire iPSC culture process, including passaging, media exchange, monitoring, and cell expansion. The system integrates an incubator, liquid handler, and AI-powered, image-based decision-making to manage feeding schedules, monitor cell growth, and initiate necessary actions. By automating these protocols, the CellXpress.ai system enhances scalability, reproducibility, and efficiency for high-throughput drug discovery and disease modeling applications.
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