Online Support

Sefia™ Expansion – Cell Expansion System

Sefia™ is a closed, automated system used for cell activation, transduction, and expansion in cell therapy manufacturing.

Sefia™ expansion system comprises three hardware components: process unit, media storage unit and status indicator as well as dedicated application software and dedicated single-use kits to provide a comprehensive solution to your cell therapy manufacturing process. This automated and functionally closed system covers cell activation, transduction and expansion resulting in a standardized process for reliable autologous cell therapy manufacturing.

Streamlined manufacturing

Using the same system via a single procedure to cover three consecutive steps of your manufacturing workflow.

Flexibility to meet your process needs.

Customizable parameters and specific kits enable the system to adapt to your individual process; accommodating all reagents and media.

Designed to increase productivity

Reduce operator touchpoints and labor hours with high level of automation over three consecutive steps to help optimize your resources and costs.

Features designed to reduce batch failure risks

Functionally closed single-use kit helps keep contaminants out. Control your process with real-time lab dashboards and alert notifications.

Easy integration

User-friendly design of applications and consumables. Centralized data traceability, consistent setup duplication and regulatory

Feature Sefia expansion system
Dimensions (W × L × H) mm System with RGB beacon: 380 × 886 × 1477 (adjustable to ± 150)

System without RGB beacon: 380 × 886 × 768

Weight Process unit: 42.2 kg Media storage unit: 38.8 kg
Power consumption 1000 W
Input voltage 100 to 240 VAC
Frequency 50/60 Hz
Core technology Two tilting platforms

2 peristaltic pumps, 16 pinch valves and 4 electro valves

Two pressure sensors

Temperature and gas control

Weight sensors on each hook and each tilting platform

Culture volume range from 125 g to 1.2 kg (up to 628 g per vessel)

CO₂ connection PMC 1603-3/16 hose barbed, non-valved connector

Minimum: 1.2 bar and maximum: 5 bar

288 L/day as maximum CO₂ consumption/leak rate

Connectivity One ethernet port and nine USB ports
Software Compatible with Sefia expansion applications only, Windows 10 and proprietary Sefia expansion software
User interface Color touchscreen with an intuitive graphical user interface (GUI) Dynamic user guide to support operations
Traceability Data management with PDF reports
User authentication Role based configuration Authentication and permission using a customer’s ActiveDirectory (AD) server
Electronic signature Electronic signature is performed in Chronicle automation software only
Data exchange Encrypted and secured
System log/audit trail Every system action is recorded in the system log

Data transfer populates associated equipment logs in Chronicle automation software