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NanoWizard V BioScience - Kính hiển vi nguyên tử lực cho ứng dụng Sinh học

NanoWizard V BioScience – Atomic Force Microscopes for Life Science

Automated quantitative nano-mechanical imaging for long-term, self-regulating experiment series.

Category: Atomic Force Microscope Tags: Atomic Force Microscope, Bruker, NanoWizard V BioScience Brand: Bruker

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0962 28 23 24

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antran@minhkhang.com.vn

Tóm tắt nội dung

The JPK NanoWizard® V combines high spatio-temporal resolution with a large scan area, flexible experiment design, and out-standing integration with advanced optical microscope systems. The automated setup, alignment, and re-adjustment of system parameters opens new possibilities for long-term, self-regulating experiment series.

Automation

Automated setup, workflow, and calibration opens new possibilities for long-term, self-regulating experiment series and complex experimental routines.

NanoMechanics

Nanomechanical characterization of single molecules, cells, tissues, and highly delicate samples thanks to advanced force control.

Fast scanning (400 lines/sec)

Study dynamic biological processes in real time via adaptive, intelligence-based scanning routines, fast force mapping and molecular recognition.

Standard Operating Modes

Now with PeakForce-QI including PeakForce Tapping, QI and PeakForce QNM
Including fast PeakForce Tapping and QI with nested scanner technology
Contact mode with lateral force microscopy (LFM)
Tapping Mode™ with PhaseImaging™
ExperimentPlanner for designing a specific measurement workflow
Static and dynamic force spectroscopy
Advanced Force Mapping

Optional Modes

Advanced spectroscopy modes such as various force clamp modes or ramp designs
Fast scanning option with line rates of up to 200 Hz
QI Advanced mode for quantitative data, perfect for soft samples
ScanAsyst automated gain and setpoint adjustment in PeakForce Tapping and PeakForce-QI
Advanced AC modes such as FM and PM with Q-control & Active Gain Control
Microrheology in CellMech Package
Kelvin Probe Microscopy
MFM and EFM
Conductive AFM
STM
Electrical spectroscopy modes
Piezoresponse Microscopy for high voltages
Electrochemistry & Scanning Electrochemistry with temperature control and optical microscopy
NanoLithography and NanoManipulation
NanoIndentation
Scanning Thermal AFM
FluidFM® solution from Cytosurge
ExperimentControl feature for remote experiment control
DirectOverlay 2 for combined AFM and optical microscopy
Additional XY or Z sample movement stages available with CellHesion®, TAO™ and HybridStage™ module

Discover the 5th Generation BioAFM

NanoWizard V is expected to significantly advance our understanding of dynamic cellular processes and molecular mechanisms. Its PeakForce-QI mode enables fast and flexible quantitative nanomechanical measurements—significantly extending the capabilities of AFM—while its automated, remote-control, and fast-scanning capabilities provide high-throughput, high-performance imaging of even complex experiments.

NanoWizard V features novel scanner and sensor technologies and state-of-the-art control software that encompasses an intuitive, workflow-based graphical user interface (GUI) to ensure true, easy-to-use AFM operation.

Unmatched ease of use
Speed for dynamics and improved throughput
Automated, high pixel density mapping and imaging
From the pioneers of BioAFM with over 25 years of experience in developing BioAFMs
Recognized by an install base of over 1000 JPK/Bruker BioAFMs across the globe
Proven by 8500+ publications with biological significance
Supported by dedicated cantilever development for high-resolution imaging and customized applications
Paving the way for new scientific discoveries with:
·       PeakForce-QI, PeakForce Tapping®, PeakForce QNM®, QI
·       Single Molecule Force Spectroscopy (SMFS)
·       Single Cell Force Spectroscopy (SCFS)
·       DirectOverlay 2 for AFM in conjunction with advanced optical microscopy
·       New software environment V8
·       Features the latest ExperimentPlanner and ExperimentControl
·       Accessories for high NA optics and AFM, environment control, and more

Latest Technology for Maximum Efficiency

Highest performance BioAFM

Featuring an enhanced, workflow-based design with intuitive user guidance in the new SPM V8 software, the NanoWizard V empowers beginners and experts alike to acquire highest quality, reproducible data. The system’s high degree of automa-tion improves productivity and maximizes throughput. State-of-the-art analysis and batch processing routines ensure scientific accuracy and statistical data reliability.

Adaptive intelligent scanning routines enable faster scanning rates of up to 400 lines/sec
Lowest noise scanner and detection system ensure high-resolution data and unrivalled performance on inverted optical microscopes
PeakForce-QI, the symbiosis of PeakForce Tapping and QI modes, delivers the fastest, most advanced force control for highly delicate samples

Fastest automated BioAFM for corrugated samples on an inverted microscope

Visualize dynamics with Bruker’s Nested Scanner and latest feedback technologies
Bruker’s proven DirectDrive increases cantilever excitation stability
Active balancing provides faster scanning over large scan ranges
Improved productivity and maximized throughput enables better statistics
Intelligent optimization routines deliver quantitative nanomechanics

Most intuitive BioAFM operations

Fundamental ease-of-use features
User management, ideal for multi-user facilities
Automated setup and workflow
Single-click cantilever calibration
Single-click optical image calibration
Extended optical viewing field for AFM with stitching feature
Long-term, unattended experimental procedures
Remote operation capabilities
Optimized storage of parameters and favorites
Intuitive integration of data processing routines

Understanding Forces in Biology

The leading BioAFM for mechanobiology

By providing the right model for the right experiment, Bruker delivers easy solutions to complex scientific questions. Automated measurement procedures allow researchers to concentrate on what’s important – their research – and to question why and not how.

Investigate single molecules, live cells, and tissue samples
Study corrugated and delicate, soft sample structures under native conditions
Gain a detailed understanding of viscoelastic properties and adhesion processes
Highest level of automation thanks to Autoalign, HybridStage or motorized stage, ExperimentPlanner, ExperimentControl, and GUI featuresfor high-speed signal processing and lowest noise levels

PeakForce-QI – a new chapter in quantitative imaging

The pioneers of quantitative biological imaging, with PeakForce Tapping (2000+ publications) and QI (~1000 publications), now bring you the next generation:
PeakForce-QI.

Fastest nanomechanical imaging thanks to latest piezo and sensor technologies
Easy, precise batch processing
True, real-time force curve monitoring

Quantitative Data and Intelligent Analysis

Automated Force Spectroscopy Reloaded

The pioneers of Single-Molecule Force Spectroscopy (SMFS) and Single-Cell Force Spectroscopy (SCFS) now bring you even more flexibility, higher precision, and increased throughput.

Proven ForceRobot technology now built-in
Bruker’s intuitive and powerful RampDesigner
Automated calibration
Molecular recognition imaging
Most sensitive force control and tip-saving features

Powerful Data-Slices

Flexible creation of topography images at different forces
Proprietary contact point imaging
Image stack output of any channel from batch processing

For complex experiments, from single molecules to cells and tissues

Optimized environmental control options
Comprehensive nano-mechanics with RampDesigner
Complex experimental routines with ExperimentPlanner

Correlated Microscopy Newly Defined

Leading BioAFM in combination with advanced optical microscopy

Perfect integration into advanced optical techniques
Optical super-resolution (STED, FLIM, …)
Upright for tissues, implants etc.
DirectOverlay 2/MIRO
One-click optical image import
980 nm OBD option
DirectTiling, for larger scale efficiency
Stitching
MultiScan
Seamless integration of multiple optical, external and AFM channels

Optical Modes Combinations

Brightfield
DIC
Phase or modulation contrast
Confocal microscopy
Spinning disc
TIRF and IRM
FRET, FLIM, FRAP, FCS
Ca²⁺ imaging
Superresolution (STED, PALM/STORM, SIM)
Macroscope combination
Optical tweezers with OT-AFM

Unrivalled Flexibility by Design

Optimized for use in microbiology and virus research

The NanoWizard V BioAFM enables direct access to pathogens and infectious agents in a BSL facility. Each step, from sample preparation, loading and disposal to running the experiment, can be performed directly in the biosafety lab.

Suitable for working with native pathogens and biohazardous material
No “additional preparation“ steps
BSL-3 compliance achieved (in accordance with lab’s safety regulations)

Bruker’s BioAFMs allow life science and biophysics researchers to further their investigations in the fields of cell mechanics and adhesion, mechanobiology, cell-cell and cell-surface interactions, cell dynamics, and cell morphology.

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