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CellHesion 300 – Atomic Force Microscopes for Life Science

Automated platform for measuring cell-cell, cell-tissue, and cell-substrate interactions with single-molecule sensitivity.

The automated CellHesion® 300 is the ideal tool for measuring cell-cell, cell-tissue, and cell-substrate interactions with single-molecule sensitivity. It enables fast and easy measurement of the structure, morphology, and nanomechanical properties of living biological systems, delivering crucial insights into the role they play in various pathological disorders. This innovative system creates novel possibilities for applications in biophysics, biochemistry, implant research, wound healing, developmental biology, stem cell research, infection biology and immune response studies.

Higher Throughput

Automated processes and increased sample size deliver the statistical significance necessary in biomedical and pre-clinical research.

SmartMapping Feature

  • Fast and easy selection of multiple regions of interest over large sample areas.
  • Flexible, user-defined 2D shaped force maps.

Label-free Measurements – Tissue Biopsies

  • Multiparametric, nanomechanical characterization of living samples in near-physiological conditions.
  • Ideal for multi-layered cell structures and soft, highly topographic tissue samples.

Understanding Biomechanics Made Easy

CellHesion 300 provides reproducible, quantitative data of unprecedented quality. Its high degree of automation increases throughput and delivers the productivity, performance, and statistical significance required for biomedical and clinical research environments. Important parameters, such as maximum adhesion force, individual unbinding events, and tether characteristics are automatically determined from each dataset by innovative software solutions.

Only CellHesion 300 delivers:

  • Maximized throughput for higher productivity by automating measurements
  • Correlative and label-free multiparametric, nanomechanical measurements of living samples in near-physiological conditions
  • Fast and simple selection of regions of interest over large sample areas, ideal for tissue biopsies
  • Systematic workflow with visual support

Performing Automated Multi-Parametric Nanomechanical Mapping

State-of-the-art software, intuitive user guidance, and automated alignment of the detection system provide the key to autonomous operation and fast results.
The new CellHesion 300 user interface gives the operator quick and easy control of the system and its operating parameters.

The software offers an easy-to-use scripting tool for user-defined experiments. Powerful batch data processing capabilities enable the analysis and quantification of large datasets at the touch of a button.

Discover the Possibilities

Mapping of the viscoelastic properties of samples with a large topography range, over an extended frequency scale with an optional Z-scanner and NestedScanner capabilities

Studying living cells under near-physiological conditions with an extensive range of accessories for control of environmental conditions, such as temperature and CO2 levels

Automate Investigation of Large Samples

The new SmartMapping feature enables the selection of flexible, user-defined 2D shaped force maps. The optimal range of force acquisition is continuously evaluated and automatically adjusted by new large-scaled Z-motors. Using optical tiling, multiple areas of interest can be selected in advance and automatically examined, allowing the easy and effective study of large sample areas. The improved motorized stage accuracy delivers a degree of precision and velocity second to none.

Integrate Seamlessly with Optical Microscopes

CellHesion 300 can be seamlessly integrated into the latest research grade optical microscopes with advanced and super-resolution capabilities, to deliver real-time, correlative data sets for the comprehensive characterization of living biological samples. Versatile experimental setups and automated adjustment
of system parameters opens new possibilities for long-term, self-regulating experiment series. CellHesion 300 is the ideal solution for the investigation of rough surfaces, densely packed cell layers, and highly corrugated tissue samples.

Bruker’s BioAFMs allow life science and biophysics researchers to further their investigations in the fields of cell mechanics and adhesion, mechanobiology, cell-cell and cell-surface interactions, cell dynamics, and cell morphology.